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How Safe is Dihydromyricetin?


Is Dihydromyricetin Safe?

The first and most important thing to know about Dihydromyricetin (DHM), is that despite its scientific sounding name, it is not a man-made chemical. Dihydromyricetin is a completely natural plant extract obtained from the oriental raisin tree Hovenia Dulcis. It is non-toxic and carries no side effects.

DHM’s safety is evidenced through scientific studies and its rich history as a hangover cure. DHM has been used in Asia for centuries as a hangover cure. The Hovenia Dulcis tree is found in Eastern China, Korea, and even in parts of the Himalayas. The seeds, leaves, and fruit are edible. Extracts of the bough, leaves, and seeds are used to make wine, candy, and even honey substitutes.

It’s popularity grew in Korea, and in 2008, the Korean Food & Drug Administration approved Hovenia Dulcis for preventing alcohol induced damage and helping the liver recover from alcohol damage. After its popularity began to grow, studies were conducted on mice revealing DHM has little to no toxicity.

Research shows Dihydromyricetin (DHM) doses far exceeding what is recommended are safe and present no serious side effects.

The following research, published on April 10, 2014, examined DHM’s acute toxicity and side effects in mice. According to the research, doses ranging from 150mg/kg to 1.5g/kg presented no significant side effects and were safe in concentration. This means doses ranging from 10.2g to 102g for a 150 pound person would not present any serious side effects.

Of course, we would not recommend taking such high doses as they are not needed. The typical dose for DHM is 300-900mg taken every three drinks consumed. The research also demonstrated that DHM actually inhibited liver cancer cell proliferation. It concluded that Dihydromyricetin (DHM) is non-cytotoxic, meaning it does not damage cells.

Why is Dihydromyricetin So Safe?

Most likely, the root cause behind DHM’s safety stems from how it works. If you haven’t consumed alcohol, DHM has absolutely no effect. But if you have consumed alcohol, it affects both your liver and your brain. Some are calling Dihydromyricetin the “antidote to alcohol”.

In the brain, alcohol binds to GABA receptors. But after it has bound to GABA receptors, it merely reduces the effect alcohol would have on them. It doesn’t stimulate them or affect them in any other way. This causes you to feel less intoxicated and more in-control while drinking, but doesn’t make you feel any different while sober.

In the liver, DHM supercharges two key enzymes; alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). The enzyme ADH is responsible for metabolizing alcohol into a toxic molecule called acetaldehyde. Research suggests acetaldehyde is over 20 times more toxic than alcohol itself and is the main culprit of many hangover symptoms. The enzyme ALDH is responsible for breaking down acetaldehyde. DHM supercharges ALDH and flushes the toxin out of your system more quickly. But again, if you haven’t consumed alcohol, enhancing these enzymes provides you with no benefit.

Dihydromyricetin only affects the way your body and brain deal with alcohol. It doesn’t get you high, or enhance your body in any other way. This is why it is so safe and non-toxic. Simply put, alcohol is a poison, and DHM is the antidote.

Please, do NOT use DHM as an excuse to consume alcohol irresponsibly. NEVER drink and drive.


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