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How Dihydromyricetin Prevents Hangovers

This article will cover how DHM is able to prevent hangovers and help you understand exactly why it works so well. Dihydromyricetin (DHM) prevents hangovers through two main mechanisms of action:

  1. DHM speeds up the body’s ability to metabolize alcohol and acetaldehyde. [2][3][4]
  2. DHM reduces the effect alcohol has on the brain’s GABA receptors.[1][3]

Acetaldehyde Metabolism and Hangover Prevention

After a person consumes alcohol, it hits the stomach, makes its way to the intestines, and is absorbed into the blood stream. Once in your blood stream, alcohol reaches your liver where it is metabolized. However, your liver metabolizes alcohol at a constant rate regardless of how much you consume. Any alcohol which can’t be metabolized by your liver circulates through your body and brain while waiting its turn to be metabolized.

Your body doesn’t metabolize alcohol into a harmless substance. It metabolizes it into acetaldehyde. Research shows that acetaldehyde is up to 10-30 times more toxic than alcohol itself. Many scientists believe alcohol is the primary cause of hangover. Symptoms of acetaldehyde poisoning include intense headaches and nausea which are also the two most common hangover symptoms.

After alcohol is metabolized into acetaldehyde it is eventually broken down into acetic acid, and eventually expelled from your body through urine and breath.

Dihydromyricetin's Role in Alcohol and Acetaldehyde Metabolism

Dihydromyricetin (DHM) increases the ability of two key enzymes to function. These enzymes are alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH). [2][3][4] The enzyme ADH is responsible for breaking down alcohol into acetaldehyde and the enzyme ALDH breaks down acetaldehyde into acetic acid. [2]

By enhancing these enzymes DHM allows you to flush both alcohol and more importantly acetaldehyde out of your system at a quicker rate. This leads to less hangover symptoms the following morning.

Why Reducing Alcohol's Effect on the GABA Receptors Prevents Hangovers

As you have previously learned, excess alcohol waiting to be metabolized by your liver circulates through your blood stream. It is at this point alcohol reaches your brain and effects two different neurotransmitter, Glutamate and GABA.

Neurotransmitters are chemical messengers your brain cells transmit between one another. They control everything from thought processes, emotions, movement, and behavior. Glutamate is an excitatory (think excite) neurotransmitter meaning it increases brain activity and energy levels. GABA is an inhibitory (think inhibit) neurotransmitter meaning it calms you down and dampens brain activity.

Alcohol binds to GABA receptors and increases the effect your brain receives from the GABA neurotransmitter. It also dampens the effect you receive from the Glutamine neurotransmitter. Amplifying GABA, an inhibitory neurotransmitter and silencing Glutamine, an excitatory neurotransmitter, gives DHM its sedative “downer” effects. At low levels one feels calm and relaxed. But at higher levels one starts to lose motor control, slur speech, and eventually pass out. At levels too high one may even experience coma and death as breathing completely stops.

After one suddenly stops consuming alcohol after a night of binge drinking their brain experiences a “rebound” effect. Since your brain was just in a state of extreme depression is then moves into a state of slight arousal. This can cause trouble sleeping, anxiety, trouble concentrating, and headaches. Think of a rubber band being held between two fingers and snapped to one side. It vibrates from one side to the other before coming to a complete stop.

Dihydromyricetin Blocks Alcohol's Effect on GABA Receptors

Dihydromyricetin helps lessen the “rebound effect” your brain experiences after consuming alcohol. DHM does this by binding to GABA receptors in your brain and blocking the effect alcohol has on them. [1][3] DHM prevents the rubber band from being stretched as far to one side. This is also why taking DHM before consuming alcohol causes one to feel less drunk and more in control.

You won’t find another substance which speeds up the breakdown of alcohol and acetaldehyde while at the same time blocking the effect alcohol has on the brain. That is also why DHM is so incredibly effective at reducing hangover symptoms.

Never Have Another Hangover

With Dihydromyricetin you never have to suffer from a hangover again, and can wake up feeling refreshed and ready to take on the day.

We're completely confident that you'll be satisfied, and if you aren't just let us know for a complete refund!

Cited Studies

For a detailed list of studies performed on Dihydromyricetin, please see our research page.

  1. Dihydromyricetin as a novel anti-alcohol intoxication medication
  2. Influence of Hovenia dulcis DHM on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking
  3. Pharmacological potential of ampelopsin (DHM) in Rattan tea
  4. Protection Against Acetaldehyde Toxicity in the Rat

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